Structure of PDB 1p7m Chain A

Receptor sequence
>1p7mA (length=187) Species: 562 (Escherichia coli) [Search protein sequence]
MERCGWVSQDPLYIAYHDNEWGVPETDSKKLFEMICLEGQQAGLSWITVL
KKRENYRACFHQFDPVKVAAMQEEDVERLVQDAGIIRHRGKIQAIIGNAR
AYLQMEQNGEPFADFVWSFVNHQPQMTQATTLSEIPTSTPASDALSKALK
KRGFKFVGTTICYSFMQACGLVNDHVVGCCCYPGNKP
3D structure
PDB1p7m Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I
ChainA
ResolutionN/A
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y16 E38 W46
Catalytic site (residue number reindexed from 1) Y16 E38 W46
Enzyme Commision number 3.2.2.20: DNA-3-methyladenine glycosylase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C4 H17 H175 C179 C4 H17 H175 C179
BS02 ADK A W6 Y13 Y16 W21 E38 W46 W6 Y13 Y16 W21 E38 W46 PDBbind-CN: -logKd/Ki=4.38,Kd=42uM
BindingDB: IC50=1500000nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008725 DNA-3-methyladenine glycosylase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006307 DNA alkylation repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1p7m, PDBe:1p7m, PDBj:1p7m
PDBsum1p7m
PubMed13129925
UniProtP05100|3MG1_ECOLI DNA-3-methyladenine glycosylase 1 (Gene Name=tag)

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