Structure of PDB 1p77 Chain A

Receptor sequence
>1p77A (length=265) Species: 727 (Haemophilus influenzae) [Search protein sequence]
MDLYAVWGNPIAQSKSPLIQNKLAAQTHQTMEYIAKLGDLDAFEQQLLAF
FEEGAKGCNITSPFKERAYQLADEYSQRAKLAEACNTLKKLDDGKLYADN
TDGIGLVTDLQRLNWLRPNQHVLILGAGGATKGVLLPLLQAQQNIVLANR
TFSKTKELAERFQPYGNIQAVSMDSIPLQTYDLVINATSASVDAEILKLG
SAFYDMQYAKGTDTPFIALCKSLGLTNVSDGFGMLVAQAAHSFHLWRGVM
PDFVSVYEQLKKAML
3D structure
PDB1p77 The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.25: shikimate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATR A G126 G128 G129 A130 N149 R150 T151 K154 T188 S189 A190 G126 G128 G129 A130 N149 R150 T151 K154 T188 S189 A190
Gene Ontology
Molecular Function
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0019632 shikimate metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1p77, PDBe:1p77, PDBj:1p77
PDBsum1p77
PubMed12837789
UniProtP43876|AROE_HAEIN Shikimate dehydrogenase (NADP(+)) (Gene Name=aroE)

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