Structure of PDB 1p5j Chain A

Receptor sequence
>1p5jA (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
GEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWA
KQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPGTTPALTIERLKNEG
ATCKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELK
ETLWEKPGAIALSVGGGGLLCGVVQGLQECGWGDVPVIAMETFGAHSFHA
ATTAGKLVSLPKITSVAKALGVKTVGSQALKLFQEHPIFSEVISDQEAVA
AIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVC
GGSNISLAQLRALKEQLGM
3D structure
PDB1p5j Crystallization and preliminary crystallographic analysis of human serine dehydratase.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K41 A65 E194 A198 S200 A222 C303
Catalytic site (residue number reindexed from 1) K38 A62 E191 A195 S197 A219 C300
Enzyme Commision number 4.3.1.17: L-serine ammonia-lyase.
4.3.1.19: threonine ammonia-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A F40 K41 N67 V167 G168 G169 G170 G171 A222 C303 G304 G305 F37 K38 N64 V164 G165 G166 G167 G168 A219 C300 G301 G302
Gene Ontology
Molecular Function
GO:0003941 L-serine ammonia-lyase activity
GO:0004794 threonine deaminase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006520 amino acid metabolic process
GO:0006565 L-serine catabolic process
GO:0006567 threonine catabolic process
GO:0006629 lipid metabolic process
GO:0009097 isoleucine biosynthetic process
GO:0042866 pyruvate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1p5j, PDBe:1p5j, PDBj:1p5j
PDBsum1p5j
PubMed14646100
UniProtP20132|SDHL_HUMAN L-serine dehydratase/L-threonine deaminase (Gene Name=SDS)

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