Structure of PDB 1p47 Chain A

Receptor sequence

>1p47A (length=87) Species: 10090 (Mus musculus) [Search protein sequence]

ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLT
THIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQ

3D structure

PDB

1p47 Constraints for Zinc Finger Linker Design as Inferred from X-ray Crystal Structure of Tandem Zif268-DNA Complexes

Chain

Resolution

2.2 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R103 R114 F116 R118 E121 R124 H125 R142 F144 S145 R146 H149 H153 T156 R170 F172 R174 E177 R180 H181 I184	R2 R13 F15 R17 E20 R23 H24 R41 F43 S44 R45 H48 H52 T55 R69 F71 R73 E76 R79 H80 I83	PDBbind-CN: Kd=2.1fM
BS02	dna	A	D120 D148 S175 D176 K179	D19 D47 S74 D75 K78	PDBbind-CN: Kd=2.1fM
BS03	ZN	A	C107 C112 H125 H129	C6 C11 H24 H28
BS04	ZN	A	C137 C140 H153 H157	C36 C39 H52 H56
BS05	ZN	A	C165 C168 H181 H185	C64 C67 H80 H84

External links

PDB	RCSB:1p47, PDBe:1p47, PDBj:1p47
PDBsum	1p47
PubMed	12818197
UniProt	P08046\|EGR1_MOUSE Early growth response protein 1 (Gene Name=Egr1)