Structure of PDB 1p2s Chain A

Receptor sequence
>1p2sA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
3D structure
PDB1p2s Organic Solvents Order the Dynamic Switch II in Ras Crystals
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S17 T35 S17 T35
BS02 GNP A G13 V14 G15 K16 S17 A18 F28 V29 D30 T35 G60 N116 K117 D119 S145 A146 K147 G13 V14 G15 K16 S17 A18 F28 V29 D30 T35 G60 N116 K117 D119 S145 A146 K147
BS03 ETF A R97 K101 D107 R97 K101 D107
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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External links
PDB RCSB:1p2s, PDBe:1p2s, PDBj:1p2s
PDBsum1p2s
PubMed12842038
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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