Structure of PDB 1p22 Chain A

Receptor sequence
>1p22A (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
SPAIMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTS
DGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFPPNSFYRALYPKIIQDI
ETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWD
KNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTL
IHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAV
NVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLV
VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIK
VWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILI
WD
3D structure
PDB1p22 Structure of a beta-TrCP1-Skp1-beta-Catenin complex: destruction motif binding and lysine specificity of the SCFbeta-TrCP1 ubiquitin ligase
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y271 R285 S309 L311 S325 L351 K365 R367 N394 G408 R431 G432 S448 R474 Y488 R521 F523 Y128 R142 S166 L168 S182 L208 K222 R224 N251 G265 R288 G289 S305 R331 Y345 R378 F380
External links
PDB RCSB:1p22, PDBe:1p22, PDBj:1p22
PDBsum1p22
PubMed12820959
UniProtQ9Y297|FBW1A_HUMAN F-box/WD repeat-containing protein 1A (Gene Name=BTRC)

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