Structure of PDB 1p0h Chain A

Receptor sequence
>1p0hA (length=290) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ALDWRSALTADEQRSVRALVTATTAVDGVAPVGEQVLRELGQQRTEHLLV
AGSRPGGPIIGYLNLSPPGGAMAELVVHPQSRRRGIGTAMARAALAKTAG
RNQFWAHGTLDPARATASALGLVGVRELIQMRRPLRDIPEPTIPDGVVIR
TYAGTSDDAELLRVNNAAFAGHPEQGGWTAVQLAERRGEAWFDPDGLILA
FGDGRLLGFHWTKVHPDHPGLGEVYVLGVDPAAQRRGLGQMLTSIGIVSL
ARRLVEPAVLLYVESDNVAAVRTYQSLGFTTYSVDTAYAL
3D structure
PDB1p0h Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.189: mycothiol synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A F174 V237 L238 V240 Q245 R246 G248 G250 Q251 A289 A290 R292 T293 F169 V226 L227 V229 Q234 R235 G237 G239 Q240 A269 A270 R272 T273
BS02 ACO A L80 V81 V82 R87 R88 G90 G92 T93 P117 A118 A120 T121 L75 V76 V77 R82 R83 G85 G87 T88 P112 A113 A115 T116
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0035447 mycothiol synthase activity
Biological Process
GO:0010125 mycothiol biosynthetic process
GO:0010126 mycothiol metabolic process
GO:0051701 biological process involved in interaction with host
GO:0070301 cellular response to hydrogen peroxide
GO:0071468 cellular response to acidic pH
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1p0h, PDBe:1p0h, PDBj:1p0h
PDBsum1p0h
PubMed12930994
UniProtP9WJM7|MSHD_MYCTU Mycothiol acetyltransferase (Gene Name=mshD)

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