Structure of PDB 1ox5 Chain A

Receptor sequence
>1ox5A (length=532) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GSHMPVVHVIDVESGNLQSLTNAIEHLGYEVQLVKSPKDFNISGTSRLIL
PGVGNYGHFVDNLFNRGFEKPIREYIESGKPIMGICVGLQALFAGSVESP
KSTGLNYIDFKLSRFDDSEKPVPEIGWNSCIPSENLFFGLDPYKRYYFVH
SFAAILNSEKKKNLENDGWKIAKAKYGSEEFIAAVNKNNIFATQFHPEKS
GKAGLNVIENFLKQQSPPIPNYSAEEKELLMNDYSNYGLTRRIIACLDVR
TNDQGDLVVTKLGKPVQLAQKYYQQGADEVTFLNITCPLKDTPMLEVLKQ
AAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFRSGADKVSIGTDAV
YAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQADTKN
KVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILL
NCIDKDGSNSGYDLELIEHVKDAVKIPVIASSGAGVPEHFEEAFLKTRAD
ACLGAGMFHRGEFTVNDVKEYLLEHGLKVRMD
3D structure
PDB1ox5 Towards Understanding the Mechanism of the Complex Cyclization Reaction Catalyzed by Imidazole Glycerophosphate Synthase:Crystal Structures of a Ternary Complex and the Free Enzyme
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D245 D404
Catalytic site (residue number reindexed from 1) D248 D386
Enzyme Commision number 3.5.1.2: glutaminase.
4.3.2.10: imidazole glycerol-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1PR A L297 I299 G331 G364 T365 S402 D404 G442 N469 D474 G475 S500 A523 G524 L283 I285 G313 G346 T347 S384 D386 G424 N451 D456 G457 S482 A505 G506
Gene Ontology
Molecular Function
GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0004359 glutaminase activity
GO:0016763 pentosyltransferase activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0016833 oxo-acid-lyase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0006541 glutamine metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:1ox5, PDBe:1ox5, PDBj:1ox5
PDBsum1ox5
PubMed12795595
UniProtP33734|HIS5_YEAST Imidazole glycerol phosphate synthase hisHF (Gene Name=HIS7)

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