Structure of PDB 1ouq Chain A

Receptor sequence

>1ouqA (length=332) Species: 10678 (Punavirus P1) [Search protein sequence]

NLPALPVDATSDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLN
NRKWFPAEPEDVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSD
SNAVSLVMRRIRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIR
NLAFLGIAYNTLLRIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGV
EKALSLGVTKLVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTR
ALEGIFEATHRLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEI
MQAGGWTNVNIVMNYIRNLDSETGAMVRLLED

3D structure

PDB

1ouq Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	F37 S38 H40 T41 A175 R243 K244 N245 R259 E262 R282 S287 G288	F28 S29 H31 T32 A166 R234 K235 N236 R250 E253 R273 S278 G279
BS02	dna	A	M44 S47 R50 R81 L83 A84 K86 T87 Q90 K132 R159 R173 K201 T202 V242 K244 L256 S257 R259 W315	M35 S38 R41 R72 L74 A75 K77 T78 Q81 K123 R150 R164 K192 T193 V233 K235 L247 S248 R250 W306

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006310	DNA recombination
GO:0015074	DNA integration

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Molecular Function

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Biological Process

External links

PDB	RCSB:1ouq, PDBe:1ouq, PDBj:1ouq
PDBsum	1ouq
PubMed	12954782
UniProt	P06956\|RECR_BPP1 Recombinase cre (Gene Name=cre)

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