Structure of PDB 1ots Chain A

Receptor sequence
>1otsA (length=444) Species: 562 (Escherichia coli) [Search protein sequence]
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMG
ALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGAL
EDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIF
RLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIK
AVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFG
PIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGG
FNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTV
LGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMT
DNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
3D structure
PDB1ots Gating the Selectivity Filter in ClC Chloride Channels
ChainA
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CL A S107 G355 I356 F357 Y445 S91 G339 I340 F341 Y429
BS02 CL A S107 P110 S91 P94
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0015297 antiporter activity
GO:0042802 identical protein binding
GO:0062158 chloride:proton antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990451 cellular stress response to acidic pH
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:1ots, PDBe:1ots, PDBj:1ots
PDBsum1ots
PubMed12649487
UniProtP37019|CLCA_ECOLI H(+)/Cl(-) exchange transporter ClcA (Gene Name=clcA)

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