Structure of PDB 1ot7 Chain A

Receptor sequence
>1ot7A (length=229) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TELTVDQQTLLDYIMDSYSKQRMPQEITNKILKEEFSAEENFLILTEMAT
SHVQILVEFTKRLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPA
GHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILS
PDRQYIKDREAVEKLQEPLLDVLQKLCKIYQPENPQHFACLLGRLTELRT
FNHHHAEMLMSWRVNDHKFTPLLCEIWDV
3D structure
PDB1ot7 Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H310 I314 K318 P460 L461 E464 H71 I75 K79 P221 L222 E225
BS02 CHC A M262 M287 A288 H291 F326 R328 S329 F333 I349 Y358 Y366 H444 M23 M48 A49 H52 F87 R89 S90 F94 I110 Y119 Y127 H205
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1ot7, PDBe:1ot7, PDBj:1ot7
PDBsum1ot7
PubMed12718893
UniProtQ62735|NR1H4_RAT Bile acid receptor (Gene Name=Nr1h4)

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