Structure of PDB 1ot5 Chain A

Receptor sequence
>1ot5A (length=477) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PVKEAEDKLSINDPLFERQWHLVNPSFPGSDINVLDLWYNNITGAGVVAA
IVDDGLDYENEDLKDNFCAEGSWDFNDNTNLPKPRLSDDYHGTRCAGEIA
AKKGNNFCGVGVGYNAKISGIRILSGDITTEDEAASLIYGLDVNDIYSCS
WGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDNC
NYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGEYIHSSD
INGRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVGLE
KNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPT
LYVSQSTNSTEETLESVITISEKSLQDANFKRIEHVTVTVDIDTEIRGTT
TVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGVGDWKIKV
KTTENGHRIDFHSWRLKLFGESIDSSK
3D structure
PDB1ot5 2.4 A Resolution Crystal Structure of the Prototypical Hormone-Processing Protease Kex2 in Complex with an Ala-Lys-Arg Boronic Acid Inhibitor
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D175 H213 N314 S385
Catalytic site (residue number reindexed from 1) D53 H91 N192 S263
Enzyme Commision number 3.4.21.61: kexin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D176 H213 L246 S272 W273 G274 P275 D277 G313 N314 D325 S385 D54 H91 L124 S150 W151 G152 P153 D155 G191 N192 D203 S263
BS02 CA A D277 D320 E350 D155 D198 E228
BS03 CA A D135 D184 K224 N227 F229 G231 D13 D62 K102 N105 F107 G109
BS04 CA A T328 S330 S333 T335 T206 S208 S211 T213
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ot5, PDBe:1ot5, PDBj:1ot5
PDBsum1ot5
PubMed12779325
UniProtP13134|KEX2_YEAST Kexin (Gene Name=KEX2)

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