Structure of PDB 1osh Chain A

Receptor sequence
>1oshA (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]
SHGELTPDQQTLLHFIMDSYNKQRMPENFLILTEMATNHVQVLVEFTKKL
PGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNS
GISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVE
KLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWR
VNDHKFTPLLCEIWDV
3D structure
PDB1osh A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FEX A N287 L291 M294 A295 S336 F340 R355 I356 M369 Y373 M454 W458 W473 N28 L32 M35 A36 S77 F81 R96 I97 M110 Y114 M195 W199 W214
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1osh, PDBe:1osh, PDBj:1osh
PDBsum1osh
PubMed12718892
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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