Structure of PDB 1os8 Chain A

Receptor sequence
>1os8A (length=223) Species: 1911 (Streptomyces griseus) [Search protein sequence]
VVGGTRAAQGEFPFMVRLSMGCGGALYAQDIVLTAAHCVSGSGNNTSITA
TGGVVDLQSSSAVKVRSTKVLQAPGYNGTGKDWALIKLAQPINQPTLKIA
TTTAYNQGTFTVAGWGANREGGSQQRYLLKANVPFVSDAACRSAYGNELV
ANEEICAGYPDTGGVDTCQGDSGGPMFRKDNADEWIQVGIVSWGYGCARP
GYPGVYTEVSTFASAIASAARTL
3D structure
PDB1os8 Engineering the Primary Substrate Specificity of Streptomyces griseus Trypsin.
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H37 D82 Q169 G170 D171 S172 G173
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N178 E180 E230 N152 E154 E208
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1os8, PDBe:1os8, PDBj:1os8
PDBsum1os8
PubMed12885239
UniProtP00775|TRYP_STRGR Trypsin (Gene Name=sprT)

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