Structure of PDB 1ork Chain A

Receptor sequence
>1orkA (length=197) Species: 562 (Escherichia coli) [Search protein sequence]
SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRAL
LDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHL
GTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEH
TAANLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV
3D structure
PDB1ork Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATC A H64 N82 F86 H100 R104 Q116 I134 S138 H63 N81 F85 H99 R103 Q115 I133 S137 MOAD: Kd=1.56nM
PDBbind-CN: -logKd/Ki=8.81,Kd=1.56nM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:1ork, PDBe:1ork, PDBj:1ork
PDBsum1ork
PubMed9878420
UniProtP0ACT4|TETR4_ECOLX Tetracycline repressor protein class D (Gene Name=tetR)

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