Structure of PDB 1ol6 Chain A

Receptor sequence
>1ol6A (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
WALEDFEIGRPLGKKFGNVYLAREKQSKFILALKVLFKAQLEKAEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDE
QRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIANFGWSVH
TLDYLPPEMIEGMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRIS
RVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANS
3D structure
PDB1ol6 Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 N274 T292
Catalytic site (residue number reindexed from 1) D126 K128 E130 N131 N144 T151
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G140 K141 K143 G145 V147 K162 A213 L263 S387 G13 K14 K15 G17 V19 K34 A83 L133 S245
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:1ol6, PDBe:1ol6, PDBj:1ol6
PDBsum1ol6
PubMed14580337
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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