Structure of PDB 1ol5 Chain A

Receptor sequence
>1ol5A (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
SKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA
GVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL
QKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKI
ADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEF
LVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRP
MLREVLEHPWITANS
3D structure
PDB1ol5 Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) D134 K136 E138 N139 D152 T170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:1ol5, PDBe:1ol5, PDBj:1ol5
PDBsum1ol5
PubMed14580337
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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