Structure of PDB 1oh5 Chain A

Receptor sequence

>1oh5A (length=788) Species: 562 (Escherichia coli) [Search protein sequence]

SAIENFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLL
DISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPAT
SKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDIS
SGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPL
WEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTT
LPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTP
MGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERI
LARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFA
ELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLE
VRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERY
IIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAE
LDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPL
NLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPID
RIFTRVGFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACA
ENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSV
QDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS

3D structure

PDB

1oh5 Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	T11 P12 M13 M33 G34 D35 F36 R58 G59 A60 P105 V106 R108	T10 P11 M12 M32 G33 D34 F35 R57 G58 A59 P104 V105 R107
BS02	dna	A	F36 E38 I53 T56 G70 P72 Y79 L495 K496 R500	F35 E37 I52 T55 G69 P71 Y78 L494 K495 R499
BS03	ADP	A	F596 I597 M617 G619 K620 S621 T622 H760	F595 I596 M616 G618 K619 S620 T621 H748

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008301	DNA binding, bending
GO:0016887	ATP hydrolysis activity
GO:0030983	mismatched DNA binding
GO:0032136	adenine/cytosine mispair binding
GO:0042802	identical protein binding
GO:0043531	ADP binding
GO:0140664	ATP-dependent DNA damage sensor activity

	Biological Process
GO:0000018	regulation of DNA recombination
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006974	DNA damage response

	Cellular Component
GO:0005829	cytosol
GO:0032300	mismatch repair complex
GO:1990710	MutS complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1oh5, PDBe:1oh5, PDBj:1oh5
PDBsum	1oh5
PubMed	12907723
UniProt	P23909\|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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