Structure of PDB 1ofo Chain A

Receptor sequence
>1ofoA (length=344) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DVRILGYDPLASPALLQVQIPATPTSLETAKRGRREAIDIITGKDDRVLV
IVGPCSIHDLEAAQEYALRLKKLSDELKGDLSIIMRAYLEKPRTTVGWKG
LINDPDVNNTFNINKGLQSARQLFVNLTNIGLPIGSEMLDTISPQYLADL
VSFGAIGARTTESQLHRELASGLSFPVGFKNGTDGTLNVAVDACQAAAHS
HHFMGVTKHGVAAITTTKGNEHCFVILRGGKKGTNYDAKSVAEAKAQLPA
GSNGLMIDYSHGNSNKDFRNQPKVNDVVCEQIANGENAITGVMIESNINE
GNQGIPAGLKYGVSITDACIGWETTEDVLRKLAAAVRQRREVNK
3D structure
PDB1ofo Substrate and Metal Complexes of 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase from Saccharomyces Cerevisiae Provide New Insights Into the Catalytic Mechanism.
ChainA
Resolution1.86 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGA A R107 G178 K201 R249 H282 R86 G157 K180 R228 H261
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1ofo, PDBe:1ofo, PDBj:1ofo
PDBsum1ofo
PubMed15019786
UniProtP32449|AROG_YEAST Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited (Gene Name=ARO4)

[Back to BioLiP]