Structure of PDB 1of6 Chain A

Receptor sequence
>1of6A (length=350) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GAEEDVRILGYDPLASPALLQVQIPATPTSLETAKRGRREAIDIITGKDD
RVLVIVGPCSIHDLEAAQEYALRLKKLSDELKGDLSIIMRAYLEKPRTVG
WKGLINDPDVNNTFNINKGLQSARQLFVNLTNIGLPIGSEMLDTISPQYL
ADLVSFGAIGARTTESQLHRELASGLSFPVGFKNGTDGTLNVAVDACQAA
AHSHHFMGVTKHGVAAITTTKGNEHCFVILRGGKKGTNYDAKSVAEAKAQ
LPAGSNGLMIDYSHGNSNKDFRNQPKVNDVVCEQIANGENAITGVMIESN
INEGNQGIPAEGKAGLKYGVSITDACIGWETTEDVLRKLAAAVRQRREVN
3D structure
PDB1of6 Evolution of Feedback-Inhibited Beta /Alpha Barrel Isoenzymes by Gene Duplication and a Single Mutation.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A C76 H282 E316 D342 C59 H264 E298 D324
BS02 DTY A T162 Q166 A169 L194 S195 T144 Q148 A151 L176 S177
BS03 DTY A E21 D22 I25 E4 D5 I8
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1of6, PDBe:1of6, PDBj:1of6
PDBsum1of6
PubMed
UniProtP32449|AROG_YEAST Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited (Gene Name=ARO4)

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