Structure of PDB 1oc4 Chain A

Receptor sequence

>1oc4A (length=315) Species: 5821 (Plasmodium berghei)

APKAKIVLVGSGMIGGVMATLIVQKNLGDVVMFDIVKNMPHGKALDTSHT
NVMAYSNCKVSGSNTYDDLKDADVVIVTAGFTKAPGKSDKEWNRDDLLPL
NNKIMIEIGGHIKNNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIVGLG
GVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQ
EFINNKKITDQELDAIFDRTINTALEIVNLHASPYVAPAAAIIEMAESYI
RDLRKVLICSTLLEGQYGHKDIFAGTPLVIGGNGVEQVIELQLNADEKKK
FDEAVAETSRMKALI

3D structure

• PDB: 1oc4 Crystal Structure of Plasmodium Berghei Lactate Dehydrogenase Indicates the Unique Structural Differences of These Enzymes are Shared Across the Plasmodium Genus
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R109 D168 R171 H195
• Catalytic site (residue number reindexed from 1): R94 D154 R157 H181
• Enzyme Commision number: 1.1.1.27: L-lactate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G27 G29 M30 I31 F52 D53 I54 Y85 T97 A98 G99 F100 T101 V138 N140 L163 L167 H195	G10 G12 M13 I14 F33 D34 I35 Y66 T78 A79 G80 F81 T82 V124 N126 L149 L153 H181

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004459 L-lactate dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0051287 NAD binding

Biological Process

• GO:0006089 lactate metabolic process
• GO:0006090 pyruvate metabolic process
• GO:0006096 glycolytic process
• GO:0019752 carboxylic acid metabolic process
• GO:0042866 pyruvate biosynthetic process

External links

• PDB: RCSB:1oc4, PDBe:1oc4, PDBj:1oc4
• PDBsum: 1oc4
• PubMed: 12967707
• UniProt: Q7SI97|LDH_PLABA L-lactate dehydrogenase (Gene Name=LDH)