Structure of PDB 1oaa Chain A

Receptor sequence
>1oaaA (length=259) Species: 10090 (Mus musculus) [Search protein sequence]
ADGLGCAVCVLTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLK
EELGAQQPDLKVVLAAADLGTEAGVQRLLSAVRELPRPEGLQRLLLINNA
ATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKT
VVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEEPSVRVLSYAPGPL
DNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLGLLQKDTFQ
SGAHVDFYD
3D structure
PDB1oaa The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OAA A S158 Y171 M206 A210 S156 Y169 M204 A208
BS02 NAP A G15 S17 R18 G19 A42 R43 S44 D70 L71 N101 A103 L127 I156 Y171 K175 P199 G200 L202 N204 M206 G13 S15 R16 G17 A40 R41 S42 D68 L69 N99 A101 L125 I154 Y169 K173 P197 G198 L200 N202 M204
Gene Ontology
Molecular Function
GO:0004757 sepiapterin reductase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006558 L-phenylalanine metabolic process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0019889 pteridine metabolic process
GO:0040014 regulation of multicellular organism growth
GO:0042415 norepinephrine metabolic process
GO:0042417 dopamine metabolic process
GO:0042428 serotonin metabolic process
GO:0046146 tetrahydrobiopterin metabolic process
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050882 voluntary musculoskeletal movement
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1oaa, PDBe:1oaa, PDBj:1oaa
PDBsum1oaa
PubMed9405351
UniProtQ64105|SPRE_MOUSE Sepiapterin reductase (Gene Name=Spr)

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