Structure of PDB 1o90 Chain A

Receptor sequence
>1o90A (length=368) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMV
LLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSP
EDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLR
PDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVI
KAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAH
GGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEP
LSISIFTYGTSKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACY
GHFGRSEFPWEVPKKLVF
3D structure
PDB1o90 Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights Into the Catalytic Mechanism
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H30 D32 K33 E58 E71 K182 F251 D259 A260 R265 K266 K286 K290 D292
Catalytic site (residue number reindexed from 1) H14 D16 K17 E42 E55 K154 F223 D231 A232 R237 K238 K258 K262 D264
Enzyme Commision number 2.5.1.6: methionine adenosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A H30 K266 H14 K238
BS02 PO4 A V205 S207 V177 S179
BS03 MG A E24 K266 E8 K238
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004478 methionine adenosyltransferase activity
GO:0005524 ATP binding
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
Biological Process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0009087 methionine catabolic process
GO:0051289 protein homotetramerization
GO:0065003 protein-containing complex assembly
Cellular Component
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0048269 methionine adenosyltransferase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1o90, PDBe:1o90, PDBj:1o90
PDBsum1o90
PubMed12888348
UniProtP13444|METK1_RAT S-adenosylmethionine synthase isoform type-1 (Gene Name=Mat1a)

[Back to BioLiP]