Structure of PDB 1o6y Chain A

Receptor sequence
>1o6yA (length=260) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSF
YLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRD
IVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAV
KVMDFGIARAIAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG
DSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAE
MRADLVRVHN
3D structure
PDB1o6y Crystal Structure of the Catalytic Domain of the Pknb Serine/Threonine Kinase from Mycobacterium Tuberculosis
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 A142 N143 D156
Catalytic site (residue number reindexed from 1) D136 K138 A140 N141 D154
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A G18 G20 G21 M22 S23 V25 A38 K40 V95 M145 D156 G16 G18 G19 M20 S21 V23 A36 K38 V93 M143 D154
BS02 MG A N143 D156 N141 D154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1o6y, PDBe:1o6y, PDBj:1o6y
PDBsum1o6y
PubMed12551895
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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