Structure of PDB 1o4o Chain A

Receptor sequence
>1o4oA (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDF
DNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL
TTVCPT
3D structure
PDB1o4o Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HPS A K54 K59 G95 L96 C97 K54 K59 G95 L96 C97 MOAD: ic50=3.5mM
PDBbind-CN: -logKd/Ki=2.46,IC50=3.5mM
BindingDB: IC50=5000000nM
BS02 HPS A R14 R34 S36 E37 H60 K62 R14 R34 S36 E37 H60 K62 MOAD: ic50=3.5mM
PDBbind-CN: -logKd/Ki=2.46,IC50=3.5mM
BindingDB: IC50=5000000nM
External links
PDB RCSB:1o4o, PDBe:1o4o, PDBj:1o4o
PDBsum1o4o
PubMed14613321
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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