Structure of PDB 1o4j Chain A

Receptor sequence
>1o4jA (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDF
DNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL
TTVCPT
3D structure
PDB1o4j Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IS2 A R14 R34 S36 E37 T38 C44 R14 R34 S36 E37 T38 C44 MOAD: ic50=4.4mM
PDBbind-CN: -logKd/Ki=2.36,IC50=4.4mM
BindingDB: IC50=4400000nM
External links
PDB RCSB:1o4j, PDBe:1o4j, PDBj:1o4j
PDBsum1o4j
PubMed14613321
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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