Structure of PDB 1o4i Chain A

Receptor sequence
>1o4iA (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDF
DNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL
TTVCPT
3D structure
PDB1o4i Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
ChainA
Resolution1.75 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 219 A R14 R34 S36 E37 T38 C44 H60 Y61 K62 R14 R34 S36 E37 T38 C44 H60 Y61 K62 PDBbind-CN: -logKd/Ki=2.64,IC50=2.3mM
BindingDB: IC50=2300000nM
External links
PDB RCSB:1o4i, PDBe:1o4i, PDBj:1o4i
PDBsum1o4i
PubMed14613321
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

[Back to BioLiP]