Structure of PDB 1o42 Chain A

Receptor sequence
>1o42A (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDF
DNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL
TTVCPT
3D structure
PDB1o42 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 843 A R14 R34 S36 E37 T38 C44 H60 Y61 K62 I73 G95 R14 R34 S36 E37 T38 C44 H60 Y61 K62 I73 G95 MOAD: ic50=9nM
PDBbind-CN: -logKd/Ki=8.05,IC50=9nM
BindingDB: IC50=9nM
External links
PDB RCSB:1o42, PDBe:1o42, PDBj:1o42
PDBsum1o42
PubMed14613321
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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