Structure of PDB 1nxc Chain A

Receptor sequence
>1nxcA (length=467) Species: 10090 (Mus musculus) [Search protein sequence]
FLPPVGVENREPADATIREKRAKIKEMMTHAWNNYKRYAWGLNELKPISK
EGHSSSLFGNIKGATIVDALDTLFIMGMKTEFQEAKSWIKKYLDFNVNAE
VSVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHTPSGIPWA
LLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGDPVFAEKVMK
IRTVLNKLDKPEGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLM
SDKTDLEAKKMYFDAVQAIETHLIRKSSGGLTYIAEWKGGLLEHKMGHLT
CFAGGMFALGADGAPEARAQHYLELGAEIARTCHESYNRTYVKLGPEAFR
FDGGVEAIATRQNEKYYILRPEVIETYMYMWRLTHDPKYRTWAWEAVEAL
ESHCRVNGGYSGLRDVYIARESYDDVQQSFFLAETLKYLYLIFSDDDLLP
LEHWIFNTEAHPFPILR
3D structure
PDB1nxc Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases
ChainA
Resolution1.51 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E282 R286 D415 E549
Catalytic site (residue number reindexed from 1) E105 R109 D238 E372
Enzyme Commision number 3.2.1.113: mannosyl-oligosaccharide 1,2-alpha-mannosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A S455 G456 S278 G279
Gene Ontology
Molecular Function
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1nxc, PDBe:1nxc, PDBj:1nxc
PDBsum1nxc
PubMed15102839
UniProtP45700|MA1A1_MOUSE Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (Gene Name=Man1a1)

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