Structure of PDB 1nwk Chain A

Receptor sequence

>1nwkA (length=354) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

TALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRSYVGDEAQSKRGILTL
KYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANRE
KMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYE
GYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLC
YVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFI
GMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEI
TALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGP
SIVH

3D structure

PDB

1nwk Crystal structure of monomeric actin in the ATP state. Structural basis of nucleotide-dependent actin dynamics.

Chain

Resolution

1.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	G268 E270	G251 E253
BS02	CA	A	D286 D288	D269 D271
BS03	CA	A	Q354 W356 E361	Q337 W339 E344
BS04	ANP	A	G13 S14 G15 L16 K18 G156 D157 G158 V159 G182 K213 E214 G302 M305 Y306 K336	G8 S9 G10 L11 K13 G139 D140 G141 V142 G165 K196 E197 G285 M288 Y289 K319
BS05	RHO	A	Y133 Y143 L346 L349 F352 M355 W356	Y116 Y126 L329 L332 F335 M338 W339

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003785	actin monomer binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005523	tropomyosin binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0019904	protein domain specific binding
GO:0031013	troponin I binding
GO:0031432	titin binding
GO:0032036	myosin heavy chain binding
GO:0042802	identical protein binding
GO:0048306	calcium-dependent protein binding
GO:0140660	cytoskeletal motor activator activity

	Biological Process
GO:0010628	positive regulation of gene expression
GO:0030041	actin filament polymerization
GO:0030240	skeletal muscle thin filament assembly
GO:0048741	skeletal muscle fiber development
GO:0051017	actin filament bundle assembly
GO:0090131	mesenchyme migration

	Cellular Component
GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005865	striated muscle thin filament
GO:0005884	actin filament
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031941	filamentous actin
GO:0032432	actin filament bundle
GO:0044297	cell body
GO:0098723	skeletal muscle myofibril

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1nwk, PDBe:1nwk, PDBj:1nwk
PDBsum	1nwk
PubMed	12813032
UniProt	P68135\|ACTS_RABIT Actin, alpha skeletal muscle (Gene Name=ACTA1)

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