Structure of PDB 1nw5 Chain A

Receptor sequence
>1nw5A (length=270) Species: 1063 (Cereibacter sphaeroides) [Search protein sequence]
GTTRHVYDVCDCLDTLAKLPDDSVQLIICDPPYNIMLADWDDHMDYIGWA
KRWLAEAERVLSPTGSIAIFGGLQYQGEAGSGDLISIISHMRQNSKMLLA
NLIIWNYPNGMSAQRFFANRHEEIAWFAKTKKYFFDLDAVREPYDEETKA
AYMKDKRLNPESVEKGRNPTNVWRMSRLNGNSLERVGHPTQKPAAVIERL
VRALSHPGSTVLDFFAGSGVTARVAIQEGRNSICTDAAPVFKEYYQKQLT
FLRSYEIVEGAANFGAALQR
3D structure
PDB1nw5 Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D65 P66
Catalytic site (residue number reindexed from 1) D30 P31
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A D46 C47 D65 H223 T225 Q226 K227 F250 G252 S253 D271 A272 D11 C12 D30 H188 T190 Q191 K192 F215 G217 S218 D236 A237 MOAD: Kd=6.1uM
PDBbind-CN: -logKd/Ki=5.21,Kd=6.1uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0009307 DNA restriction-modification system
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1nw5, PDBe:1nw5, PDBj:1nw5
PDBsum1nw5
PubMed12732637
UniProtP14751|MTR1_CERSP Type II methyltransferase M.RsrI (Gene Name=rsrIM)

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