Structure of PDB 1nuo Chain A

Receptor sequence
>1nuoA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
MEELQKSIGHKPEPTDEEWELIKTVTEAHVATNAGSHWKQKRKFLPDDIG
QDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIM
SLHAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSF
NLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHH
VTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB1nuo Two resistance to thyroid hormone mutants with impaired hormone binding
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4HY A F269 F272 I275 I276 A279 M310 M313 H316 A317 N331 L346 H435 F455 F56 F59 I62 I63 A66 M97 M100 H103 A104 N118 L133 H222 F242 BindingDB: IC50=0.0407nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1nuo, PDBe:1nuo, PDBj:1nuo
PDBsum1nuo
PubMed12554782
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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