Structure of PDB 1nu9 Chain A

Receptor sequence
>1nu9A (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
GEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVML
FRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSR
TRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPV
CLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIV
ERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNR
WYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
3D structure
PDB1nu9 Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H75 D131 E234 G235 D236 S237 G238
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0ZJ A H57 Y60A W60D L99 I174 D189 A190 S195 S214 W215 G216 G219 H75 Y79 W82 L128 I211 D231 A232 S237 S258 W259 G260 G262
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1nu9, PDBe:1nu9, PDBj:1nu9
PDBsum1nu9
PubMed14523451
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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