Structure of PDB 1nu2 Chain A

Receptor sequence

>1nu2A (length=152) Species: 10090 (Mus musculus) [Search protein sequence]

GQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVV
AGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITD
HRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEK
KA

3D structure

PDB

1nu2 Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R56 V110 H111 I113 S114 Y115 I116 A117 G131 K132 I151 R155 F158 Y162	R34 V88 H89 I91 S92 Y93 I94 A95 G109 K110 I129 R133 F136 Y140
BS02	I3P	A	K45 R76 H81 K82 R124 K142	K23 R54 H59 K60 R102 K120

External links

PDB	RCSB:1nu2, PDBe:1nu2, PDBj:1nu2
PDBsum	1nu2
PubMed	12737822
UniProt	P97318\|DAB1_MOUSE Disabled homolog 1 (Gene Name=Dab1)

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