Structure of PDB 1nsd Chain A

Receptor sequence
>1nsdA (length=390) Species: 11525 (Influenza B virus (STRAIN B/BEIJING/1/87)) [Search protein sequence]
EPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKE
CKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAA
WSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQE
SACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEE
CTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTP
RPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMG
MELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCDVPCIG
IEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
3D structure
PDB1nsd Influenza B virus neuraminidase can synthesize its own inhibitor.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D148 E275 R291 R373 Y408
Catalytic site (residue number reindexed from 1) D73 E200 R216 R298 Y333
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D292 T296 D323 G343 G345 D217 T221 D248 G268 G270
BS02 DAN A R115 E116 D148 R149 W176 R222 A244 E274 R291 R373 Y408 R40 E41 D73 R74 W101 R147 A169 E199 R216 R298 Y333
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1nsd, PDBe:1nsd, PDBj:1nsd
PDBsum1nsd
PubMed8069621
UniProtP27907|NRAM_INBBE Neuraminidase (Gene Name=NA)

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