Structure of PDB 1nqc Chain A

Receptor sequence
>1nqcA (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVTLSA
QNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQ
YDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRS
GVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMAR
NKGNHCGIASFPSYPEI
3D structure
PDB1nqc Specificity determinants of human cathepsin s revealed by crystal structures of complexes.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H164 N184
Catalytic site (residue number reindexed from 1) Q19 C25 H164 N184
Enzyme Commision number 3.4.22.27: cathepsin S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C4P A G23 C25 K64 C66 G68 G69 F70 M71 V162 N163 G23 C25 K64 C66 G68 G69 F70 M71 V162 N163 PDBbind-CN: -logKd/Ki=7.30,Ki=50nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1nqc, PDBe:1nqc, PDBj:1nqc
PDBsum1nqc
PubMed12641451
UniProtP25774|CATS_HUMAN Cathepsin S (Gene Name=CTSS)

[Back to BioLiP]