Structure of PDB 1nq7 Chain A

Receptor sequence
>1nq7A (length=244) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREA
LWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRM
CRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEE
EIALFSSAVLISPDRAWLLEPRKVQKLQEKIYFALQHVIQKNHLDDETLA
KLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFN
3D structure
PDB1nq7 All-trans retinoic acid is a ligand for the orphan nuclear receptor RORbeta
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K278 Q288 I292 P444 E448 K71 Q81 I85 P237 E241
BS02 ARL A C227 Q228 Y229 L300 V303 R306 M307 F330 C20 Q21 Y22 L93 V96 R99 M100 F123 MOAD: Ki=0.16uM
PDBbind-CN: -logKd/Ki=6.80,Ki=0.16uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:1nq7, PDBe:1nq7, PDBj:1nq7
PDBsum1nq7
PubMed12958591
UniProtP45446|RORB_RAT Nuclear receptor ROR-beta (Gene Name=Rorb)

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