Structure of PDB 1nq0 Chain A

Receptor sequence
>1nq0A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
AAMEELQKSIGHKPEPTDEEWELIKTVTEAHVATNTQGSHWKQKRKFLPE
DIGQKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGC
CMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGM
SLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYIN
YRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEV
FED
3D structure
PDB1nq0 Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4HY A F269 F272 I276 M310 M313 A317 R320 L330 N331 L346 H435 M442 F61 F64 I68 M102 M105 A109 R112 L122 N123 L138 H227 M234 PDBbind-CN: -logKd/Ki=10.32,IC50=0.048nM
BindingDB: IC50=0.0407nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1nq0, PDBe:1nq0, PDBj:1nq0
PDBsum1nq0
PubMed12511610
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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