Structure of PDB 1npc Chain A

Receptor sequence
>1npcA (length=317) Species: 1396 (Bacillus cereus) [Search protein sequence]
VTGTNKVGTGKGVLGDTKSLNTTLSGSSYYLQDNTRGATIFTYDAKNRST
LPGTLWADADNVFNAAYDAAAVDAHYYAGKTYDYYKATFNRNSINDAGAP
LKSTVHYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVT
ENSSNLIYQNESGALNEAISDIFGTLVEFYDNRNPDWEIGEDIYTPGKAG
DALRSMSDPTKYGDPDHYSKRYTGSSDNGGVHTNSGIINKQAYLLANGGT
HYGVTVTGIGKDKLGAIYYRANTQYFTQSTTFSQARAGAVQAAADLYGAN
SAEVAAVKQSFSAVGVN
3D structure
PDB1npc The structure of neutral protease from Bacillus cereus at 0.2-nm resolution.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H143 E144 H147 Y158 E167 D227 H232
Catalytic site (residue number reindexed from 1) H143 E144 H147 Y158 E167 D227 H232
Enzyme Commision number 3.4.24.28: bacillolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D139 E178 D186 E188 E191 D139 E178 D186 E188 E191
BS02 CA A E178 N184 D186 E191 E178 N184 D186 E191
BS03 CA A D58 D60 V62 D58 D60 V62
BS04 CA A Y194 T195 K198 D201 Y194 T195 K198 D201
BS05 ZN A H143 H147 E167 H143 H147 E167
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1npc, PDBe:1npc, PDBj:1npc
PDBsum1npc
PubMed1633827
UniProtP05806|NPRE_BACCE Bacillolysin (Gene Name=npr)

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