Structure of PDB 1nn1 Chain A

Receptor sequence
>1nn1A (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
RRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLL
SSYLQKKSDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGV
AFTGAKENFSLDWCKQPDVGLPKPDLVLFLQLQLADAAKRGAFGHERYEN
GAFQERALRCFHQLMKDTTLNWKMVDASKSIEAVHEDIRVLSEDAIATAT
EKPLGELWK
3D structure
PDB1nn1 Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2DT A F42 L57 F72 R76 R97 G102 F105 F39 L54 F69 R73 R94 G99 F102
BS02 ANP A D15 R16 G18 K19 S20 T21 R143 I184 D12 R13 G15 K16 S17 T18 R140 I181
Gene Ontology
Molecular Function
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0043627 response to estrogen
GO:0045445 myoblast differentiation
GO:0046105 thymidine biosynthetic process
GO:0046686 response to cadmium ion
GO:0046940 nucleoside monophosphate phosphorylation
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1nn1, PDBe:1nn1, PDBj:1nn1
PDBsum1nn1
PubMed12614151
UniProtP23919|KTHY_HUMAN Thymidylate kinase (Gene Name=DTYMK)

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