Structure of PDB 1nlu Chain A

Receptor sequence

>1nluA (length=368) Species: 306 (Pseudomonas sp.) [Search protein sequence]

GTAKGHNPTEFPTIYDASSAPTAANTTVGIITIGGVSQTLQDLQQFTSAN
GLASVNTQTIQTGSSNGDYSDDQQGQGEWDLDSQSIVGSAGGAVQQLLFY
MADQSASGNTGLTQAFNQAVSDNVAKVINVSLGWCEADANADGTLQAEDR
IFATAAAQGQTFSVSSGDEGVYECNNRGYPDGSTYSVSWPASSPNVIAVG
GTTLYTTSAGAYSNETVWNEGLDSNGKLWATGGGYSVYESKPSWQSVVSG
TPGRRLLPDISFDAAQGTGALIYNYGQLQQIGGTSLASPIFVGLWARLQS
ANSNSLGFPAASFYSAISSTPSLVHDVKSGNNGYGGYGYNAGTGWDYPTG
WGSLDIAKLSAYIRSNGF

3D structure

PDB

1nlu Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate.

Chain

Resolution

1.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	E80 D84 D170 S287
Catalytic site (residue number reindexed from 1)	E78 D82 D168 S285
Enzyme Commision number	3.4.21.100: sedolisin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	I35 D74 E80 W81 L134 G135 W136 G169 D170 E175 R179 S190 G285 S287	I33 D72 E78 W79 L132 G133 W134 G167 D168 E173 R177 S188 G283 S285
BS02	peptide	A	E80 E222 W231 Q268 Q281 I283 G284	E78 E220 W229 Q266 Q279 I281 G282
BS03	CA	A	D328 V329 G344 G346 D348	D326 V327 G342 G344 D346

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1nlu, PDBe:1nlu, PDBj:1nlu
PDBsum	1nlu
PubMed	14733955
UniProt	P42790\|PICP_PSESR Pseudomonalisin (Gene Name=pcp)

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