Structure of PDB 1njj Chain A

Receptor sequence
>1njjA (length=349) Species: 31285 (Trypanosoma brucei gambiense) [Search protein sequence]
NTRDALCKKGDPFFVADLGDIVRKHETWKKCLPRVTPFYAVKCNDDWRVL
GTLAALGTGFDCASNTEIQRVRGIGVPPEKIIYANPCKQISHIRYARDSG
VDVMTFDCVDELEKVAKTHPKAKMVLRISTVKFGAKVEDCRFILEQAKKL
NIDVTGVSFHVGSGSTDASTFAQAISDSRFVFDMGTELGFNMHILDIGGG
FPGTRDAPLKFEEIAGVINNALEKHFPPDLKLTIVAEPGRYYVASAFTLA
VNVIAKKVTQSFMYYVNDGVYGSFNCILYDHAVVRPLPQREPEKLYPSSV
WGPTCDGLDQIVERYYLPEMQVGEWLLFEDMGAYTVSPTIYYVVSGLPD
3D structure
PDB1njj X-ray Structure Determination of Trypanosoma brucei Ornithine Decarboxylase Bound to D-Ornithine and to G418: INSIGHTS INTO SUBSTRATE BINDING AND ODC CONFORMATIONAL FLEXIBILITY.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K69 H197 E274
Catalytic site (residue number reindexed from 1) K42 H160 E237
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GET A R22 D243 L339 L382 E384 D385 R3 D206 L287 L327 E329 D330 MOAD: Ki=8mM
PDBbind-CN: -logKd/Ki=2.10,Ki=8mM
BS02 ORX A A67 K69 H197 G236 G237 E274 G276 R277 Y331 D332 Y389 A40 K42 H160 G199 G200 E237 G239 R240 Y279 D280 Y334 MOAD: Kd=0.27mM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0016829 lyase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0033387 putrescine biosynthetic process from ornithine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1njj, PDBe:1njj, PDBj:1njj
PDBsum1njj
PubMed12672797
UniProtQ9TZZ6

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