Structure of PDB 1nhz Chain A

Receptor sequence

>1nhzA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]

PTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAK
AIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLII
NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDG
LKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNNIKKLLFHQ

3D structure

PDB

1nhz The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain: RU-486 INDUCES A TRANSCONFORMATION THAT LEADS TO ACTIVE ANTAGONISM.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	486	A	M560 L563 N564 G567 Q570 M601 M604 F623 Q642 M646 L732	M31 L34 N35 G38 Q41 M72 M75 F94 Q113 M117 L203	PDBbind-CN: -logKd/Ki=6.08,Ki=0.84uM BindingDB: IC50=1.1nM,Ki=1.2nM,EC50=872nM,Kd=15nM

External links

PDB	RCSB:1nhz, PDBe:1nhz, PDBj:1nhz
PDBsum	1nhz
PubMed	12686538
UniProt	P04150\|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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