Structure of PDB 1ng9 Chain A

Receptor sequence

>1ng9A (length=794) Species: 562 (Escherichia coli) [Search protein sequence]

MSAIENFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQL
LDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPA
TSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDI
SSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRP
LWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRT
TLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVT
PMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLER
ILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEF
AELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERL
EVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAER
YIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALA
ELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANP
LNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPI
DRIFTRVGAGRSTFMVEMTETANILHNATEYSLVLMDEIGAGTSTYDGLS
LAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTI
AFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS

3D structure

PDB

1ng9 The alternating ATPase domains of MutS control DNA mismatch repair

Chain

Resolution

2.6 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	P12 M13 M33 G34 D35 F36 S61 Q95 P99 P105 V106 R108	P12 M13 M33 G34 D35 F36 S61 Q95 P99 P105 V106 R108	PDBbind-CN: Kd=9.6uM
BS02	dna	A	F36 E38 I53 S54 T56 M68 G70 P72 H74 Y79 L495 K496 R500	F36 E38 I53 S54 T56 M68 G70 P72 H74 Y79 L495 K496 R500	PDBbind-CN: Kd=9.6uM
BS03	ADP	A	L592 F596 I597 N616 M617 G619 K620 S621 T622 H760	L592 F596 I597 N616 M617 G619 K620 S621 T622 H754

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008301	DNA binding, bending
GO:0016887	ATP hydrolysis activity
GO:0030983	mismatched DNA binding
GO:0032136	adenine/cytosine mispair binding
GO:0042802	identical protein binding
GO:0043531	ADP binding
GO:0140664	ATP-dependent DNA damage sensor activity

	Biological Process
GO:0000018	regulation of DNA recombination
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006974	DNA damage response

	Cellular Component
GO:0005829	cytosol
GO:0032300	mismatch repair complex
GO:1990710	MutS complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:1ng9, PDBe:1ng9, PDBj:1ng9
PDBsum	1ng9
PubMed	12554674
UniProt	P23909\|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

[Back to BioLiP]