Structure of PDB 1nf8 Chain A

Receptor sequence
>1nf8A (length=207) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
MSGIPEITAYPLPTAQQLPANLARWSLEPRRAVLLVHAMQRYFLRPLPES
LRAGLVANAARLRRWCVEQGVQIAYTAQPGSMTEEQRGLLKDFWGPGMRA
SPADREVVEELAPGPDDWLLTKWRYSAFFHSDLLQRMRAAGRDQLVLCGV
YAHVGVLISTVDAYSNDIQPFLVADAIADFSEAHHRMALEYAASRCAMVV
TTDEVLE
3D structure
PDB1nf8 Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H37 A38 K122
Catalytic site (residue number reindexed from 1) H37 A38 K122
Enzyme Commision number 3.3.2.15: trans-2,3-dihydro-3-hydroxyanthranilic acid synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ISC A F43 Q78 R87 W94 K122 V150 Y151 G155 F43 Q78 R87 W94 K122 V150 Y151 G155 MOAD: Kd=0.015uM
PDBbind-CN: -logKd/Ki=7.82,Kd=0.015uM
Gene Ontology
Molecular Function
GO:0008908 isochorismatase activity
GO:0016787 hydrolase activity
Biological Process
GO:0002047 phenazine biosynthetic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1nf8, PDBe:1nf8, PDBj:1nf8
PDBsum1nf8
PubMed12741825
UniProtP0DPB9|PHZD1_PSEAE Phenazine biosynthesis protein PhzD1 (Gene Name=phzD1)

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