Structure of PDB 1nf7 Chain A

Receptor sequence
>1nf7A (length=454) Species: 9606 (Homo sapiens) [Search protein sequence]
TSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKI
TLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKK
YEQGFITDPVVLSPKGIISSRDIDFLEHDCFLEEIMTKREDLVVAPAGIT
LKEANEILQRSKKGKLPIVNEDDELVAIIARTLKKNRDYPLASKDAKKQL
LCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKY
PNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQA
TAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATT
EAPGEYFFSDGIRLKKYRGMGSLDAMIKVAQGVSGAVQDKGSIHKFVPYL
IAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYE
KRLF
3D structure
PDB1nf7 Crystal Structure of Human Inosine Monophosphate Dehydrogenase type II complexed with the MPA/NAD analog C2-MAD
ChainA
Resolution2.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RVP A S68 M70 G328 S329 I330 C331 D364 S388 G413 M414 G415 Q441 G442 S59 M61 G284 S285 I286 C287 D320 S344 G369 M370 G371 Q381 G382
BS02 MYD A T252 H253 D274 S275 S276 F282 N303 G324 G326 C331 T333 T208 H209 D230 S231 S232 F238 N259 G280 G282 C287 T289 BindingDB: Ki=250nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
GO:0007623 circadian rhythm
GO:0046651 lymphocyte proliferation
GO:0071353 cellular response to interleukin-4
GO:0097294 'de novo' XMP biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1nf7, PDBe:1nf7, PDBj:1nf7
PDBsum1nf7
PubMed
UniProtP12268|IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (Gene Name=IMPDH2)

[Back to BioLiP]