Structure of PDB 1ne4 Chain A

Receptor sequence
>1ne4A (length=268) Species: 9913 (Bos taurus) [Search protein sequence]
ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIA
GETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTP
RAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD
KWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENE
EFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
PCSDILKRNIQQYNSFVS
3D structure
PDB1ne4 Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RP1 A V182 F198 G199 E200 L201 A202 R209 A210 W260 V74 F90 G91 E92 L93 A94 R101 A102 W152
BS02 RP1 A V300 F322 G323 E324 I325 A326 R333 A334 A335 Y371 N372 S373 V192 F214 G215 E216 I217 A218 R225 A226 A227 Y263 N264 S265
Gene Ontology
Molecular Function
GO:0008603 cAMP-dependent protein kinase regulator activity
Biological Process
GO:0001932 regulation of protein phosphorylation
Cellular Component
GO:0005952 cAMP-dependent protein kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ne4, PDBe:1ne4, PDBj:1ne4
PDBsum1ne4
PubMed15157095
UniProtP00514|KAP0_BOVIN cAMP-dependent protein kinase type I-alpha regulatory subunit (Gene Name=PRKAR1A)

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