Structure of PDB 1nax Chain A

Receptor sequence
>1naxA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPE
GGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCM
EIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYR
KHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB1nax Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.
ChainA
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IH5 A F272 I275 I276 R282 M310 M313 L330 N331 H435 F455 F62 I65 I66 R72 M100 M103 L120 N121 H225 F245 PDBbind-CN: -logKd/Ki=6.43,Ki=0.37uM
BindingDB: IC50=1.1nM,Ki=0.37nM,EC50=1.12nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1nax, PDBe:1nax, PDBj:1nax
PDBsum1nax
PubMed12699376
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

[Back to BioLiP]