Structure of PDB 1nav Chain A

Receptor sequence
>1navA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
HMEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAKQRRKFLPDDIGQSP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCC
MEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKS
LSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNH
RKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVF
EDQ
3D structure
PDB1nav Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IH5 A F218 I222 A225 M256 M259 L276 S277 G290 L292 H381 M388 F401 F63 I67 A70 M101 M104 L121 S122 G135 L137 H226 M233 F246 BindingDB: IC50=25nM,Ki=7.18nM,EC50=11nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1nav, PDBe:1nav, PDBj:1nav
PDBsum1nav
PubMed12699376
UniProtP10827|THA_HUMAN Thyroid hormone receptor alpha (Gene Name=THRA)

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