Structure of PDB 1n8w Chain A

Receptor sequence
>1n8wA (length=718) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
VSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALL
NARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSG
VDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGA
EKGPTYNKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVAL
PDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIEILIDPESQVGTTDR
AGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLAAAVA
FLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVF
EGIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPAEVAFT
CELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTG
FLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRA
QVGKGMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVD
VAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDNNCQSILGYV
VRWVDQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVR
ASLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGY
TEPILHRRRREFKARAAE
3D structure
PDB1n8w Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D271 E273 R339 E434 D462 D633
Catalytic site (residue number reindexed from 1) D267 E269 R330 E425 D453 D624
Enzyme Commision number 2.3.3.9: malate synthase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 MG A E434 D462 E425 D453
BS02 COA A V118 V119 R125 F126 N129 S275 R312 P543 P545 C619 S620 K621 M631 D633 V114 V115 R121 F122 N125 S271 R303 P534 P536 C610 S611 K612 M622 D624
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001968 fibronectin binding
GO:0003824 catalytic activity
GO:0004474 malate synthase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0016740 transferase activity
GO:0042803 protein homodimerization activity
GO:0043236 laminin binding
GO:0046810 host cell extracellular matrix binding
GO:0046872 metal ion binding
GO:0120225 coenzyme A binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0009436 glyoxylate catabolic process
GO:0015936 coenzyme A metabolic process
GO:0044406 adhesion of symbiont to host
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009986 cell surface
GO:0042603 capsule

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1n8w, PDBe:1n8w, PDBj:1n8w
PDBsum1n8w
PubMed12393860
UniProtP9WK17|MASZ_MYCTU Malate synthase G (Gene Name=glcB)

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